Chiral pharmaceutical drug adsorption to natural and synthetic particulates in water and their desorption in simulated gastric fluid

Natural and synthetic particulates in aquatic environments can act as a vector for chiral pharmaceutical drugs. Understanding enantiomer enrichment the particulate phase of water matrices is essential considering enantiospecific effects that drugs have on exposed organisms. Therefore, adsorption cationic fluoxetine propranolol to polyhydroxyalkanoate bioplastic, polyamide microplastic, cellulose was investigated 0.01 M calcium chloride (CaCl2) buffer real environmental matrices. Fluoxetine enantiomers adsorbed all types under conditions studied. Yet, only CaCl2 at pH 11, samples prepared using (river wastewater). No enantioselectivity observed or propranolol, their subsequent desorption simulated gastric environment. Findings showed enantiomeric composition drug will reflect dissolved assuming no degradation takes place. However, further studies are now needed broader range matter found water. Importantly, considerably greater river wastewater compared (2.1 5.3 times fluoxetine). Most reported literature use conform with international guidelines assessing behaviour chemicals. Although such enable direct comparison similar studies, they underestimate engineered natural environments. This needs consideration future microplastics other laboratory studies.